Scientific studies demonstrate the efficacy of the first component of Alpha-HgH®: Alpha-GPC

Enzymes in the brain split a-Glycerylphosphorylcholine (Alpha-GPC) into Glycerolphosphate and Choline and easily cross the blood-brain barrier for the synthesis of phosphatidylcholine and acetylcholine, both essential for the maintenance and function of neuronal brain cells.

Alpha-GPC (alpha-glycerylphosphorylcholine) is a phospholipid which provides a uniquely non-electrically-charged source of choline. This lack of charge most likely accounts for its ability to pass over the blood-brain-barrier. Studies (Abbiati-1993) show that Alpha-GPC increases free plasma choline more quickly than other uncharged choline precursors.
Another major benefit of Alpha-GPC seems to hinge on its unique molecular structure. A simple enzymatic process easily breaks Alpha-GPC into two components: Glycerolphosphate and choline. These two pieces easily pass through the blood-brain-barrier and each provides particular benefit to enhanced brain function.
The Glycerolphosphate molecule is quickly converted into phosphatidylcholine which is used to repair and replace damaged and/or aging membranes of brain cells.
Choline is used to synthesize the essential neurotransmitter, acetylcholine. Acetylcholine is the vehicle used to carry all electronic messages from the end of one nerve cell to the receptor of the next.
Through the years, many substances have been tested and drugs have been developed to enhance memory and brain function. To date, nothing seems to be as effective or have as lasting effect at Alpha-GPC.
What follows is a summary of some of the recent studies comparing Alpha-GPC with other agents.

Studies Show Alpha-GPC Superior to Cytidine Diphosphocholine in Improving Memory, Cognitive Skills, and Behavior Parameters

Three multicenter studies with diagnosed with Multi-Infarct Dementia, (MID), compared Alpha-GPC with cytidine diphosphocholine (CDP). The first study (Di Perri) demonstrated that Alpha-GPC was significantly superior to CDP in improving memory functions.

The second study (Frattola) showed that Alpha-GPC provides faster and more complete improvement in thinking skills, somatic functioning, memory, and word fluency.

In the third study (Muratorio) Alpha-GPC treatment significantly improved memory, cognitive skills, and behavioral parameters throughout the 3 month study. The Alpha-GPC subjects also showed very high improvement at the follow up examination 30 days beyond the cessation of treatment.

Alpha-GPC superior to Cytidine diphosphocholine (CDP) for improving memory and thinking skills in Geriatric Patients using Sandoz Clinical Assessment (SCAG) Scale
Alpha-GPC superior to Cytidine diphosphocholine (CDP) for improving memory and thinking skills in Geriatric Patients using Improvement Blessed Score
Alpha-GPC superior to Cytidine diphosphocholine (CDP) for improving memory and thinking skills in Geriatric Patients using Wechsler Memory Scale (WMS)
Alpha-GPC superior to Cytidine diphosphocholine (CDP) for improving memory and thinking skills in Geriatric Patients using Rapid Disability Rating Scale (RDRS-2) Scale

Animal Studies Suggest Daily Alpha-GPC Use Counters Neuron Loss and Memory Loss

Researchers (Ricci) report that daily Alpha-GPC supplementation "counteracts some anatomical changes of the rat hippocampus occurring in old age." Neurons in the hippocampus relay information to the cerebellum. There are other studies that show Alpha-GPC also helps restore acetylcholine receptor sites. The number of these important sites tends to decrease with age.

Amnesia has been directly tied to blocked or decreased levels of acetylcholine. As a result, scientists have used this phenomenon to evaluate the ability of Alpha-GPC to reverse this damage.

In a recent study (Lopez) the oral administration of Alpha-GPC reverses amnesia and partially counteracts the loss of acetylcholine in the brain induced by the drug scopolamine.

Researchers in another study (Sigala) found that oral administration of Alpha-GPC actually prevented learning impairment and was able to reverse scopolamine-induced amnesia.

Scientific studies demonstrate efficacy of the second Alpha-HgH® component - Homeopathic HgH

Several studies have confirmed and reconfirmed that injectable HGH provides many age-reversing benefits. The question remains, can a homeopathic form of HGH produce the same effects? This is an important question because the cost of injectable HGH therapy puts it out of reach of most - without even considering the fact that many are adverse to injections in the first place.

A few researchers have attempted to answer this question. One such study (Brewitt) was lead by a former researcher at the National Institutes of Health. The study included a set of three double-blind, placebo-controlled trials. These researchers found that homeopathic HGH significantly increased body mass and simultaneously decreased overall body weight, body fat, increased mental clarity, increased libido, improved breathing, improved skin softness, and improved sleep quality over those in the placebo group.

One of these trials, a 21-day double-blind, cross-over study, concluded that homeopathic HGH significantly increased lean body mass and simultaneously decreased overall body weight, body fat, and blood pressure.

Another study (Culik) measured the change in serum IGF-1 levels in a 30-day double blind study with homeopathic HGH. Insulin-like Growth Factor 1 (IGF-1) is a polypeptide protein hormone produced in the liver, usually in response to the presence of HGH. Because HGH only remains in the blood for about 20 minutes, researchers most often monitor IGF-1 to determine the amount of HGH that is produced over time.

The Culik study measured an increase in IGF-1 that was nearly 2.5 times that of the placebo controls. In addition, subjects rated changes in a group of 10 clinical areas tied to increase of serum HGH. Subjects receiving homeopathic HGH reported significant improvement in 7 of the 10 areas. The researchers concluded that oral administration homeopathic HGH did indeed contribute to beneficial increases in HGH levels.

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