The Science behind Alpha-HgHTM
NOTE: The scientific basis for each of the two major components of Alpha-HgH® is extensive and rich. Many studies attest to the efficacy and safety of alpha glycerylphosphorylcholine and of homeopathic HgH. This report is but a small summary of some of the results from a sampling of the studies.
Scientific studies demonstrate the efficacy of the first component of Alpha-HgHTM Alpha-GPC
Alpha-GPC (alpha-glycerylphosphorylcholine) is a phospholipid which provides a uniquely non-electrically-charged source of choline. This lack of charge most likely accounts for its ability to pass over the blood-brain-barrier. Studies (Abbiati-1993) show that Alpha-GPC increases free plasma choline more quickly than other uncharged choline precursors.
|Enzymes in the brain split a-Glycerylphosphorylcholine (Alpha-GPC) into Glycerolphosphate and Choline and easily cross the blood-brain barrier for the synthesis of phosphatidylcholine and acetylcholine, both essential for the maintenance and function of neuronal brain cells.|
Another major benefit of Alpha-GPC seems to hinge on its unique molecular structure. A simple enzymatic process easily breaks Alpha-GPC into two components: Glycerolphosphate and choline. These two pieces easily pass through the blood-brain-barrier and each provides particular benefit to enhanced brain function.
The Glycerolphosphate molecule is quickly converted into phosphatidylcholine which is used to repair and replace damaged and/or aging membranes of brain cells.
Choline is used to synthesize the essential neurotransmitter, acetylcholine. Acetylcholine is the vehicle used to carry all electronic messages from the end of one nerve cell to the receptor of the next.
Through the years, many substances have been tested and drugs have been developed to enhance memory and brain function. To date, nothing seems to be as effective or have as lasting effect at Alpha-GPC.
What follows is a summary of some of the recent studies comparing Alpha-GPC with other agents.
Alpha-GPC superior to acetyl-l-carnitine in Improving Thinking and Memory
|Alpha-GPC superior to acetyl-l-carnitine (ST200) in SDAT Study in improving memory and thinking skills as measured by Mini Mental State Examination (MMSE)|
|Results as reported by Parnetti L, et al, "Multicentre study of l-a-glyceryl- phosphorylcholine vs. ST200 among patients with probable Senile Dementia of Alzheimer's Type" Drugs & Aging, No. 3 (2), 1993.|
Subjects treated with Alpha-GPC obtained greater improvement of their general and cognitive conditions than those treated with ST200. In particular, Alpha-GPC treatment produced significantly better results as measured by the GGS and SCAG scales (universally-used psychometric and physiologic tests for evaluating thinking and memory ability in age-related brain dysfunction) resulting in a higher quality of life for Alpha-GPC treated individuals and their families.
Studies Show Alpha-GPC Superior to Cytidine Diphosphocholine in Improving Memory, Cognitive Skills, and Behavior Parameters
|Three multicenter studies with diagnosed with Multi-Infarct Dementia, (MID), compared Alpha-GPC with cytidine diphosphocholine (CDP). The first study (Di Perri) demonstrated that Alpha-GPC was significantly superior to CDP in improving memory functions.|
The second study (Frattola) showed that Alpha-GPC provides faster and more complete improvement in thinking skills, somatic functioning, memory, and word fluency.
In the third study (Muratorio) Alpha-GPC treatment significantly improved memory, cognitive skills, and behavioral parameters throughout the 3 month study. The Alpha-GPC subjects also showed very high improvement at the follow up examination 30 days beyond the cessation of treatment.
Clinical Trials Demonstrate Alpha-GPC Superior to Oxiracetam in Boosting Memory Ability
Two studies with a total of 90 subjects with moderately severe Age Associated Memory Impairment compared Alpha-GPC and Oxiracetam. One trial (Abbati) showed similar, positive results for both agents until the 8th post-treatment follow up week. Positive residual effects of Alpha-GPC were consistently better than Oxiracetam's results.
Alpha-GPC subjects performed much better than Oxiracetam with rating scale scores and psychometric tests in a second study (Paciaroni and Tomassini).
Animal Studies Suggest Daily Alpha-GPC Use Counters Neuron Loss and Memory Loss
Researchers (Ricci) report that daily Alpha-GPC supplementation "counteracts some anatomical changes of the rat hippocampus occurring in old age." Neurons in the hippocampus relay information to the cerebellum. There are other studies that show Alpha-GPC also helps restore acetylcholine receptor sites. The number of these important sites tends to decrease with age.
Amnesia has been directly tied to blocked or decreased levels of acetylcholine. As a result, scientists have used this phenomenon to evaluate the ability of Alpha-GPC to reverse this damage.
In a recent study (Lopez) the oral administration of Alpha-GPC reverses amnesia and partially counteracts the loss of acetylcholine in the brain induced by the drug scopolamine.
Researchers in another study (Sigala) found that oral administration of Alpha-GPC actually prevented learning impairment and was able to reverse scopolamine-induced amnesia.
Human Performance Tests Show Alpha-GPC Increases HGH, Strength and Muscle Power
Human Growth Hormone|
Recent placebo-controlled tests performed by the Ohio Institute of Health and human Performance, showed Alpha-GPC doubles growth hormone response in the first 30 minutes after exercise.
Peak Force and Peak Generation
The same tests showed that subjects were able to generate approximately 14% more peak force during six sets of squats when given an oral administration of Alpha-GPC 90 minutes prior to the exercise. These subjects also produced an average of 13% more peak power during the same exercise.
Based on the researchers' discovery of a lower Respiratory Exchange Rate (RER) levels in the same subjects, they suggest that Alpha-GPC may also increase fat metabolism during the post-exercise period.
|Alpha-GPC Produces Substantial Increase in Peak Bench Press Force|
Scientific studies demonstrate efficacy of the second Alpha-HgHTM component — Homeopathic HgH
Several studies have confirmed and reconfirmed that injectable HGH provides many age-reversing benefits. The question remains, can a homeopathic form of HGH produce the same effects? This is an important question because the cost of injectable HGH therapy puts it out of reach of most — without even considering the fact that many are adverse to injections in the first place.
A few researchers have attempted to answer this question. One such study (Brewitt) was lead by a former researcher at the National Institutes of Health. The study included a set of three double-blind, placebo-controlled trials. These researchers found that homeopathic HGH significantly increased body mass and simultaneously decreased overall body weight, body fat, increased mental clarity, increased libido, improved breathing, improved skin softness, and improved sleep quality over those in the placebo group.
One of these trials, a 21-day double-blind, cross-over study, concluded that homeopathic HGH significantly increased lean body mass and simultaneously decreased overall body weight, body fat, and blood pressure.
Another study (Culik) measured the change in serum IGF-1 levels in a 30-day double blind study with homeopathic HGH. Insulin-like Growth Factor 1 (IGF-1) is a polypeptide protein hormone produced in the liver, usually in response to the presence of HGH. Because HGH only remains in the blood for about 20 minutes, researchers most often monitor IGF-1 to determine the amount of HGH that is produced over time.
The Culik study measured an increase in IGF-1 that was nearly 2.5 times that of the placebo controls. In addition, subjects rated changes in a group of 10 clinical areas tied to increase of serum HGH. Subjects receiving homeopathic HGH reported significant improvement in 7 of the 10 areas. The researchers concluded that oral administration homeopathic HGH did indeed contribute to beneficial increases in HGH levels.
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